Large arteriolar component of oxygen delivery implies safe margin of oxygen supply to cerebral tissue

نویسندگان

  • Sava Sakadžić
  • Emiri T. Mandeville
  • Louis Gagnon
  • Joseph J. Musacchia
  • Mohammad A. Yaseen
  • Meryem A Yucel
  • Joel Lefebvre
  • Frédéric Lesage
  • Anders M. Dale
  • Katharina Eikermann-Haerter
  • Cenk Ayata
  • Vivek J. Srinivasan
  • Eng H. Lo
  • Anna Devor
  • David A. Boas
چکیده

(a) Maximum intensity projection (MIP) of the 200-µm-thick cortical microvascular stack obtained by TPM. Blood plasma was labeled by FITC. (b) Top-view projection of the segmented microvasculature with the intravascular PO 2 measurements obtained by TPM. Mean vascular segment PO 2 measurements were color-coded and overlaid on the segmented microvascular structure. (c) MIP of the OCT image of the red blood cell velocity projections to the microscope optical axis in the upper 150-µm-tick segment of the microvasculature. The OCT data was previously co-registered with the vascular stack in a. (d) Top-view projection of the segmented microvasculature obtained by TPM, with the co-registered OCT measurements of the blood flow. Measured blood flow values in penetrating arterioles and surfacing venules were color-coded and overlaid on the segmented microvascular structure. Scale bars, 200 µm.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2014